Endocrine Abstracts

Sheehan syndrome is a global or partial pituitary defect occurring after an obstetrical haemorrhage.The aim of this study is to describe metabolic complications in 46 consecutive patients with Sheehan syndrome and to determine correlations between these complications and the clinical, hormonal and therapeutic aspects of this syndrome.All patients have had a physical examination: weight measurement, body mass index (BMI) determinati...

We present a 58 years old woman admitted in our department for bradycardia, diarrhea, epigastralgia, anorexia and weight loss. Physical examination showed low blood pressure and inability to walk or stand due to severe flexion contractures of the lower extremities without neurological abnormalities. The biological findings showed severe hyponatremia, hyerkaliemia tendency, low levels of plasma cortisol and ACTH suggesting pituitary adrenal axis deficiency. Hormonal investigati...

IntroductionPheochromocytomas are rare catecholamine-producing neuroendocrine tumors derived from the sympathetic or parasympathetic nervous system. The clinical presentation of pheocromocytoma has varying forms, which makes diagnosing it challenging. Here, we report a case of Adrenergic cardiomyopathy mimicking COVID-19.Case reportA 40-year-old woman with a history of pulmonary edema during cesarean delivery...

BackgroundHypoglycemia is a well-established as a serious paraneoplastic complication of hepatocellular carcinoma (HCC). However, hypoglycemia presenting the first presentation of HCC is not frequent. In this regard, we present the case of a patient who had hypoglycemia as first manifestation of HCC.ObservationA 55yearold man presented to the Emergency Department with loss of consciousness preceded by dizzine...

IntroductionInsulinoma is the most frequent pancreatic endocrine tumor and is confirmed in case of a hyperinsulinic hypoglycemia with elevated C-peptide and absence of sulfonylureas. Tomodensitometry, MRI, endoscopic ultrasound are the imaging means used to assess localization before surgery as it is not always determined by one mean only, and in a few cases, all means may not determine localization.MethodsTh...

IntroductionSpontaneous hypoglycemia in non-diabetic adults represent a challenge in confirming the organic cause, requiring in that case specific medication or surgery, in a setting of a possible life-threatening disease.MethodsWe conducted a retrospective study of patients admitted in our department for spontaneous hypoglycemia. Functional and factitious etiology were excluded. Clinical and biologic feature...

IntroductionThe empty sella syndrome is a rare disorder characterized by a flattened pituitary gland leaving place to the cerebrospinal fluid to fill in the sella turcica.The diagnosis is radiological and it is often discovered during pituitary disorders. Generally patients suffer from hypopituitarism, and primary hypothyroidism is found to be a rare association.ObservationHerein the case of a young woman who...

IntroductionHyperthyroidism is a very common disease due to an overactive thyroid gland. Antithyroid drugs (ATD) represent the first line treatement. Their side effects can be severe and even potentially fatal. Among them, agranulocytosis, defined as an absolute neutrophils count less than 500/µl is the most feared one.ObservationWe report the case of 57 year-old woman with no medical history, recently d...

IntroductionThe atypical parathyroid adenoma is a histological diagnosis. It is a parathyroid tumor with atypical histological features different from an adenoma and not similar enough to be considered as a carcinoma.It has an uncertain malignant potential.ObservationWe report the case of a 55 year-old woman, referred to us by her rhumatologist after discovering a severe hypercalcemia when exploring her for o...

BackgroundPrimary hyperparathyroidism (PHPT) results from inappropriate overproduction of parathyroid hormone from one or more of parathyroid glands with consequent hypercalcemia. Medical therapy by bisphosphonates is indicated for patients contraindicated for surgical treatment or those with therapy failure. We report the observation of a patient receiving zoledronic acid for persistent PHPT and who developped bisphosphonate-related osteonecrosis of the...